Tom P. Aufderheide,
MD; Gardar Sigurdsson, MD;
Ronald G. Pirrallo, MD, MHSA; Demetris
Yannopoulos, MD; Scott McKnite,
BA; Chris von Briesen, BA,
From the Department of Emergency Medicine, Medical College of Wisconsin, Milwaukee (T.P.A., R.G.P., C.J.C.); Advanced Circulatory Systems, Inc, Eden Prairie, Minn (C.v.B., C.W.S., T.A.P., K.G.L.); and the Cardiac Arrhythmia Center, Departments of Internal Medicine and Emergency Medicine, Hennepin County Medical Center, University of Minnesota, Minneapolis (G.S., D.Y., S.M.).
Correspondence to Keith G. Lurie, MD, Box 508, UMHC, 420 Delaware Street SE, Minneapolis, MN 55455. E-mail firstname.lastname@example.org
Received October 22, 2003; revision received December 30, 2003; accepted February 2, 2004.
Background— A clinical observational study revealed that rescuers consistently hyperventilated patients during out-of-hospital cardiopulmonary resuscitation (CPR). The objective of this study was to quantify the degree of excessive ventilation in humans and determine if comparable excessive ventilation rates during CPR in animals significantly decrease coronary perfusion pressure and survival.
Methods and Results— In humans, ventilation rate and duration during CPR was electronically recorded by professional rescuers. In 13 consecutive adults (average age, 63±5.8 years) receiving CPR (7 men), average ventilation rate was 30±3.2 per minute (range, 15 to 49). Average duration per breath was 1.0±0.07 per second. No patient survived. Hemodynamics were studied in 9 pigs in cardiac arrest ventilated in random order with 12, 20, or 30 breaths per minute. Survival rates were then studied in 3 groups of 7 pigs in cardiac arrest that were ventilated at 12 breaths per minute (100% O2), 30 breaths per minute (100% O2), or 30 breaths per minute (5% CO2/95% O2). In animals treated with 12, 20, and 30 breaths per minute, the mean intrathoracic pressure (mm Hg/min) and coronary perfusion pressure (mm Hg) were 7.1±0.7, 11.6±0.7, 17.5±1.0 (P<0.0001), and 23.4±1.0, 19.5±1.8, and 16.9±1.8 (P=0.03), respectively. Survival rates were 6/7, 1/7, and 1/7 with 12, 30, and 30+ CO2 breaths per minute, respectively (P=0.006).
Conclusions— Professional rescuers were observed to excessively ventilate patients during out-of-hospital CPR. Subsequent animal studies demonstrated that similar excessive ventilation rates resulted in significantly increased intrathoracic pressure and markedly decreased coronary perfusion pressures and survival rates.
Key Words: cardiopulmonary resuscitation • death, sudden • heart arrest • ventilation • hypotension